The basic features of the Nephrotic Syndrome (NS) is large proteinuria, hypoproteinemia, (height) edema and hyperlipidemia, namely the so-called "three high and one low, and other metabolic disorders for the characteristics of a group of clinical syndrome. If you have any question please ask our ONLINE DOCTOR. We will give professional guidance as soon as possible.
1. large amount of proteinuria
Proteinuria is the main clinical manifestation of NS patients, and is also the most basic pathophysiological mechanism of nephrotic syndrome. A large number of protein urine is the adult urine protein excretion 3.5g/d. In normal physiological conditions, the glomerular filtration membrane has a molecular barrier and charge barrier, which leads to the increase of the content of protein in the urine, and forms a large amount of protein urine when it is absorbed by the proximal tubule.
2. low protein
Plasma albumin to 30g/L. NS, a large amount of albumin was lost from the urine, which promotes the increase of the liver compensatory synthesis of albumin and renal tubular. When the increase in liver albumin synthesis is not sufficient to overcome the loss and breakdown, the low serum albumin level appears. In addition, patients with NS due to gastrointestinal mucosa edema lead to poor appetite and protein intake insufficiency, malabsorption or loss, but also increase the cause of hypoalbuminemia.
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