The emergence of proteinuria means that renal function has been damaged. If not controlled in time, the more protein leakage, the more serious the damage of glomerular filtration membrane, the greater the harm to renal function.
In the final analysis, the formation of proteinuria is caused by impaired renal filtration function. Inflammatory reactions occur in the kidney, resulting in damage to kidney cells, glomeruli, tubules and other tissues, leading to changes in the kidney tissue, unable to play a normal role in regulation, filtration and metabolism.
How should Kidney Disease patients deal with Proteinuria?
In the course of clinical treatment, the treatment of proteinuria needs to be divided into two parts: internal treatment and external treatment.
Internal therapy mainly inhibits protein leakage from the source, generally divided into three stages:
1. In the stage of renal inflammation, proteinuria leaks slightly. Urinary routine manifestations are usually urinary protein +, and 24-hour urinary protein quantification is less than 1 g. This stage generally does not need hormone treatment, can take the control diet with traditional Chinese medicine method to inhibit protein leakage, we need to pay attention to avoid overtreatment.
If the patients with proteinuria take hormone treatment inappropriately, resulting in decreased immunity, increase the risk of infection, but will exacerbate the leakage of proteinuria, damage renal function.
2. The stage of renal insufficiency. At the same time, the increase of proteinuria slowed down. Active treatment can stabilize at a lower level.
Renal insufficiency is a turning point in the treatment of the whole kidney disease. If some factors such as proteinuria can be controlled in time to accelerate the deterioration of renal failure, most patients with kidney disease can remain at this stage and stay away from renal failure.
At this stage, hypoprotein therapy is still dominated by hormones and immunosuppressive agents. For patients with unsatisfactory hypoprotein effect, adjuvant medications can be increased, including pril or sartan antihypertensive drugs, statins antihypertensive drugs, etc. These drugs can also reduce blood pressure caused by nephropathy while assisting in reducing proteinuria. The elevation of blood lipid has the effect of delaying renal function.
At this stage, in addition to adjusting medication, there is also a treatment focus, that is, the prevention of infection. The key to prevent infection is to enhance self-immunity. Kidney friends should improve their daily diet, work-rest adjustment and exercise.
3. Stage of renal failure and end-stage renal disease.
Proteinuria exists throughout the development of kidney disease. At the stage of renal failure, protein leakage decreases gradually, and the damage to the remaining renal function decreases. In this stage, besides continuing to take drugs to treat protein reduction. More importantly, it is important to prevent and treat sudden complications and protect the residual renal function.
Including hypertension, anemia, hyperkalemia, hyperphosphorus and so on, these complications will increase the risk of serious complications such as cardiovascular disease of nephropathy, renal osteopathy, and in turn accelerate the progress of renal failure.
Therefore, to control proteinuria, these complications are the focus of treatment. Long-term adherence to the review of indicators, targeted drug use, adherence to good dietary habits, can reduce the incidence of these complications.
Uremia stage, especially in dialysis patients, due to the limitation of urine volume, proteinuria is generally not too much. It is important to protect renal function and stabilize toxin excretion.
Except for the repeated proteinuria caused by the characteristics of nephropathy and proteinuria itself, it is difficult to eliminate it completely. Some external factors are also responsible for refractory proteinuria.
Some inducing factors, such as infection, high protein diet, excessive fatigue, medication and so on, may interrupt the rhythm of treatment, and then lead to frequent recurrence of proteinuria. Nephropathy patients should strengthen their own prevention of these factors and recur regularly.
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