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How Does Cyclophosphamide Help for IgA Nephropathy

Provided by Expert Yang Hongtao on : 2013-12-06 14:23

How Does Cyclophosphamide Help for IgA NephropathyHow does cyclophosphamide help for IgA Nephropathy? In clinic, this medication is commonly used alone or in combination with other medications to treat certain types of kidney disease including IgA Nephropathy.

Effects of cyclophosphamide for IgA Nephropathy

At first, this medication is created to fight against cancer. Later, it is proven to have obvious immunosuppressive action, so it can help treat kidney disease which is caused by abnormal immune system.

IgA Nephropathy is one condition where a lot of immunoglobulin A (IgA) deposits in glomerular mesangial area, and this is due to the disorders of immune system and abnormal immune reaction. Therefore, cyclophosphamide can bring the following benefits for IgA Nephropathy patients:

- Alleviate proteinuria and swelling

- Slow the progress of this disease

- Inhibit immune reaction

- Protect further kidney damage

Even though cyclophosphamide does help quite a number of people with IgA Nephropathy manage their illness condition, most of these patients suffer from one or more side effects of this medication.

Side effects of cyclophosphamide

Because of its functional mechanism, this drug will weaken patients’ immunity and cause the following side effects.

- Nausea and vomiting

- Loss of appetite or weight

- Getting infections, fever or chill frequently

- Changes in skin color or skin itching

- Hair loss

- Shortness of breath

Besides, this treatment can’t treat IgA Nephropathy from the root, because it can do nothing to deal with the deposits of IgA and repair damaged kidney cells. Therefore, to treat IgA Nephropathy fundamentally, Immunotherapy may be needed.

Compared with simple immunosuppressants, Immunotherapy focuses on removing waste products and toxins from the body and prompting the restoration of damaged kidney cells. Also, one step of this treatment, immune adjustment, has an effect of regulating immune system, so as to prevent the recurrence of IgA Nephropathy.

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