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What Drugs May Cause Increased Creatinine Levels

Provided by Expert Yang Hongtao on : 2014-02-07 09:55

What Drugs May Cause Increased Creatinine LevelsWhat drugs may cause increased creatinine level? Creatinine, one by-product of creatine, is used commonly in lab to check how well kidneys are working. If it is higher than 1.3mg/dl, it shows increased creatinine levels. Besides kidney disease, some drugs can also cause elevated creatinine levels. What are they?

Which kinds of drugs or medications may cause creatinine level to rise?

Creatinine is one muscle metabolism waste that is discharged out of the body by kidneys. Also, it may result from dehydration, floated high blood pressure, kidney infection, strenuous exercise, etc. From this point, medications that can provoke these problem are more likely to elevate creatinine level. Among them, some drugs that can damage kidneys are common to see.

If your high creatinine is due to medications as follows, try to reduce your dosage or stop them.

1. Antibiotics

Antibiotics are used to fight against bacterial infections like urinary tract infections. However, most antibiotics are excreted via urine, that is to say, they have renal toxicity. Antibiotics such as penicillin and aminoglycoside may cause kidney damage and increased creatinine level easily.

2. Painkillers

If you experience frequent back pain, headache or pain in other regions, you must be familiar with painkillers. Ibuprofen, naproxen, aspirin and some other non-steroidal anti-inflammatory drugs (NSAIDS) may be the inducement of high creatinine levels.

3. Cyclosporine

Cyclosporine, as one immunosuppressant, is taken to prevent rejection of transplanted organs such as kidneys and liver or treat autoimmune disorders. However, overdosage of cyclosporine can lead to irreversible kidney damage.


ACEI (angiotensin converting enzyme inhibits) is given to lower high blood pressure and reduce the protein amount in urine, but patients should avoid them experience narrowing of the arterial vessels in kidneys. This is because these medications in this case can cause further kidney damage and elevate creatinine level in the blood.

Additionally, many other drugs like diuretics and chemotherapy medications may also cause increased creatinine level. Since the words here are limited, we can’t list them one by one. If you are interested about this topic, you can contact us. We are glad to share them with you in detail.


It is quite hard to fight against kidney disease for a long time. Now, a lot of kidney experts here try to give biggest help for kidney patients. If you have some questions about any kind of kidney disease, welcome to contact us by the following ways.

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