When creatinine produced by muscle metabolism is released into the blood, it is serum creatinine. The clearance rates of serum creatinine and creatinine were not consistent, and the clearance rates of Creatinine were more sensitive than that of serum creatinine.
In the early stage of renal dysfunction (compensatory phase), creatinine clearance decreased while serum creatinine was normal. When the glomerular filtration rate drops to more than 50% of the normal level, the serum creatinine begins to rise rapidly. Therefore, when the serum creatinine is significantly higher than the normal level, it often indicates that the renal function has been seriously damaged.
Since creatinine clearance is also affected by the function of glomerular concentration, serum creatinine is a reliable indicator of glomerular function in the case of impaired renal concentration. Normal male serum creatinine was 53-106 gmol/L, while female serum creatinine was 44.2-97.2 gmol/L.
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