What is Focal Segmental Glomerulosclerosis (FSGS)?
As we know each person has two kidneys, and each kidney is made up of approximately one million tiny filters called “glomeruli”. The glomeruli have the function of keeping the valuable cells and protein in the blood. When glomeruli is damaged, proteins begin leaking out into the urine (proteinuria). The prolonged leakage of protein can cause kidney damage and even failure. Focal Segmental Glomerulosclerosis (FSGS) is a rare disease which attacks the glomeruli causing serious scarring. FSGS is one of the causes of a serious condition known as Nephrotic Syndrome.
Do you know the main causes of Focal Segmental Glomerulosclerosis (FSGS)?
1.The main causes of FSGS can be divided into two sides: the internal reason like reduced immunity and the external reason like antigens of infection, cold etc. With the decrease of immunity, the pathologic foreign bodies which are some type of antigens will combined with antibody after invading into human body, and then form immune complex.
2.The special epitopes in the kidneys can attract the immune complexes, then the immune complexes will flow with the blood circulation and deposit in the glomerular capillary loops. Then the epithelial cells of the glomerulus will become segmental hyaline degeneration. Therefore, the surface of epithelial cells of glomerulus is desquamation, and ethe inflammatory mediator will invade continually, which will cause the damages of epithelial cells barrier function. Proteins in the blood will leak out into the urine, and then get discharged of body. Meanwhile, when the epithelial cells get damaged,they will turn into myofibroblast, which is resulted in glomerular sclerosis. Then the process of renal fibrosis will start.
In these cases, the disease can be caused by:
- Born with too few glomeruli.
- Massive obesity.
- Various infections such as HIV, parvovirus and hepatitis B.
- Medications or toxins.
- Chronic systemic diseases and other chronic kidney diseases.
These are the common causes of FSGS. If you are suffering from this kind of kidney disease, don’t feel too worry about that, having treatments timely and effectively can make you recover to a healthy life.