Diabetic Nephropathy has a series of symptoms such as, nausea, vomiting, fatigue, poor appetite, proteinuria, swelling, hematuria, anemia. Here i will share the causes of edema in diabetic nephropathy.
1. The systemic capillary wall permeability increases due to the body immune damage in patients with diabetic nephropathy, which leads to water infiltration into tissue spaces.
2. When the kidneys are induced by diabetes, the blood perfusion of the two kidneys will be reduced, the renal parenchyma is ischemic and anoxic, and the renin secretion will increase. Through the action of renin angiotensin, the adrenal cortex will increase the secretion of aldosterone, resulting in the increase of water and sodium reabsorption and retention of renal tubules.
3. When diabetic nephropathy suffers from kidney disease, the leakage of protein increases gradually with the aggravation of the disease. The long-term existence of proteinuria aggravates the damage of kidney and forms hypoproteinemia, which reduces the plasma colloid osmotic pressure, and causes extracellular fluid to stay in the interstitial space, causing edema. In addition, hypoalbuminemia can also lead to reduced effective blood volume, resulting in secondary aldosterone and antidiuretic hormone secretion increased, renal tubular reabsorption of water, sodium increased, resulting in edema.
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